Movement Disorders (revue)

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Abnormal visual activation in Parkinson's disease patients

Identifieur interne : 001E71 ( Main/Exploration ); précédent : 001E70; suivant : 001E72

Abnormal visual activation in Parkinson's disease patients

Auteurs : Ellison Fernando Cardoso [Brésil] ; Felipe Fregni [États-Unis] ; Fernanda Martins Maia [Brésil] ; Luciano M. Melo [Brésil] ; João R. Sato [Brésil] ; Antonio Cesário Cruz Jr. [Brésil] ; Edno Tales Bianchi [Brésil] ; Danilo Botelho Fernandes [Brésil] ; Mário Luiz Ribeiro Monteiro [Brésil] ; Egberto Reis Barbosa [Brésil] ; Edson Amaro Jr. [Brésil]

Source :

RBID : ISTEX:F5F2D61684EF6FB4C9015D0D39B4EB4D3317DB17

English descriptors

Abstract

Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society

Url:
DOI: 10.1002/mds.23101


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<div type="abstract" xml:lang="en">Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</div>
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